Neurotrypsin-Agrin system

Vrijbloed JW, Hettwer S, Dahinden P, Kucsera S, Fariello RG. Agrin serum levels as a marker of sarcopenia. Program No. 867.11/X12. 2010 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2010, p 709. Download pdf

Vrijbloed J, Hettwer S, Dahinden P, Kucsera S, Fariello R. Involvement of the neurotrypsin-agrin axis in sarcopenia. 2010. European Federation of Neurological Societies © 2010 EFNS European Journal of Neurology 17 (Suppl. 3) p 537. Download pdf

Bolliger MF, Zurlinden A, Luscher D, Butikofer L, Shakhova O, Francolini M, Kozlov SV, Cinelli P, Stephan A, Kistler AD, Rulicke T, Pelczar P, Ledermann B, Fumagalli G, Gloor SM, Kunz B, Sonderegger P. Specific proteolytic cleavage of agrin regulates maturation of the neuromuscular junction. J Cell Sci, 2010; 123: 3944-55. PubMed Abstract

Matsumoto-Miyai K, Sokolowska E, Zurlinden A, Gee CE, Luscher D, Hettwer S, Wolfel J, Ladner AP, Ster J, Gerber U, Rulicke T, Kunz B, Sonderegger P. Coincident pre- and postsynaptic activation induces dendritic filopodia via neurotrypsin-dependent agrin cleavage. Cell, 2009; 136: 1161-71. PubMed Abstract

Frischknecht R, Fejtova A, Viesti M, Stephan A, Sonderegger P. Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin. J Neurosci, 2008; 28: 1568-79. Download pdf

Stephan A, Mateos JM, Kozlov SV, Cinelli P, Kistler AD, Hettwer S, Rulicke T, Streit P, Kunz B, Sonderegger P. Neurotrypsin cleaves agrin locally at the synapse. FASEB J, 2008; 22: 1861-73. Download pdf

Reif R, Sales S, Hettwer S, Dreier B, Gisler C, Wolfel J, Luscher D, Zurlinden A, Stephan A, Ahmed S, Baici A, Ledermann B, Kunz B, Sonderegger P. Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation. FASEB J, 2007; 21: 3468-78. Download pdf

Molinari F, Rio M, Meskenaite V, Encha-Razavi F, Auge J, Bacq D, Briault S, Vekemans M, Munnich A, ttie-Bitach T, Sonderegger P, Colleaux L. Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation. Science, 2002; 298: 1779-81. PubMed Abstract

 

Sarcopenia

G. Abellan Van Kan, J.M. Cedarbaum, M. Cesari, P. Dahinden, R.G. Fariello, R.A. Fielding, B.H. Goodpaster, S. Hettwer, M. Isaac, D. Laurent, J.E. Morley, M. Pahor, D. Rooks, R. Roubenoff, S.B. Rutkove, A. Shaheen, S. Vamvakas, J.W. Vrijbloed, B. Vellas Sarcopenia: BIOMARKERS AND IMAGING (International Conference on Sarcopenia Research). Report on the Journal of Nutrition, Health & Aging © (Volume 15, Number 10, 2011). PubMed Abstract

Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing, 2010; 39: 412-23. Download pdf

Bauer JM, Kaiser MJ, Sieber CC. Sarcopenia in nursing home residents. J Am. Med. Dir. Assoc., 2008; 9: 545-51. PubMed Abstract

Borst SE. Interventions for sarcopenia and muscle weakness in older people. Age Ageing, 2004; 33: 548-55. Download pdf