On Pubmed

Link to CAF and agrin related publications by Neurotune.


Selected publications on agrin

Neurotrypsin-Agrin system

Hettwer S, Lin S, Kucsera S, Haubitz M, Oliveri F, Fariello RG, Ruegg MA, Vrijbloed JW. Injection of a Soluble Fragment of Neural Agrin (NT-1654) Considerably Improves the Muscle Pathology Caused by the Disassembly of the Neuromuscular Junction. PLoS One. 2014 Feb 10;9(2):e88739. doi: 10.1371/journal.pone.0088739. eCollection 2014.
Pubmed Abstract

Bolliger MF, Zurlinden A, Luscher D, Butikofer L, Shakhova O, Francolini M, Kozlov SV, Cinelli P, Stephan A, Kistler AD, Rulicke T, Pelczar P, Ledermann B, Fumagalli G, Gloor SM, Kunz B, Sonderegger P. Specific proteolytic cleavage of agrin regulates maturation of the neuromuscular junction. J Cell Sci, 2010; 123: 3944-55. PubMed Abstract

Matsumoto-Miyai K, Sokolowska E, Zurlinden A, Gee CE, Luscher D, Hettwer S, Wolfel J, Ladner AP, Ster J, Gerber U, Rulicke T, Kunz B, Sonderegger P. Coincident pre- and postsynaptic activation induces dendritic filopodia via neurotrypsin-dependent agrin cleavage. Cell, 2009; 136: 1161-71. PubMed Abstract

Frischknecht R, Fejtova A, Viesti M, Stephan A, Sonderegger P. Activity-induced synaptic capture and exocytosis of the neuronal serine protease neurotrypsin. J Neurosci, 2008; 28: 1568-79. Download pdf

Stephan A, Mateos JM, Kozlov SV, Cinelli P, Kistler AD, Hettwer S, Rulicke T, Streit P, Kunz B, Sonderegger P. Neurotrypsin cleaves agrin locally at the synapse. FASEB J, 2008; 22: 1861-73. Download pdf

Reif R, Sales S, Hettwer S, Dreier B, Gisler C, Wolfel J, Luscher D, Zurlinden A, Stephan A, Ahmed S, Baici A, Ledermann B, Kunz B, Sonderegger P. Specific cleavage of agrin by neurotrypsin, a synaptic protease linked to mental retardation. FASEB J, 2007; 21: 3468-78. Download pdf

Molinari F, Rio M, Meskenaite V, Encha-Razavi F, Auge J, Bacq D, Briault S, Vekemans M, Munnich A, ttie-Bitach T, Sonderegger P, Colleaux L. Truncating neurotrypsin mutation in autosomal recessive nonsyndromic mental retardation. Science, 2002; 298: 1779-81. PubMed Abstract


Drey M, Grösch C, Neuwirth C, Bauer JM, Sieber CC. The Motor Unit Number Index (MUNIX) in sarcopenic patients. Experimental Gerentology Journal 2013 Jan 31. PubMed Abstract

Cesari M, Fielding RA, Pahor M, Goodpaster B, Hellerstein M, Van Kan GA, Anker SD, Rutkove S, Vrijbloed JW, Isaac M, Rolland Y, M’rini C, Aubertin-Leheudre M, Cedarbaum JM, Zamboni M, Sieber CC, Laurent D, Evans WJ, Roubenoff R, Morley JE, Vellas B; International Working Group on Sarcopenia. Biomarkers of sarcopenia in clinical trials-recommendations from the International Working Group on Sarcopenia. Journal of Cachexia Sarcopenia Muscle 2012 Aug 3. PubMed Abstract

Drey M, Sieber CC, Bauer JM, Uter W, Dahinden P, Fariello RG, Vrijbloed JW; the FiAT intervention group. C-terminal Agrin Fragment as a potential marker for sarcopenia caused by degeneration of the neuromuscular junction. Experimental Gerentology Journal 2012 Jun 7. PubMed Abstract

Hettwer S., Dahinden P., Kucsera S., Farina C., Ahmed S., Fariello R., Drey M., Sieber CC., Vrijbloed JW., Elevated levels of a C-terminal agrin fragment identifies a new subset of sarcopenia patients.[nbsp]Report on the Experimental Gerentology Journal[nbsp](March 11, 2012). Publication

Abellan Van Kan, J.M. Cedarbaum, M. Cesari, P. Dahinden, R.G. Fariello, R.A. Fielding, B.H. Goodpaster, S. Hettwer, M. Isaac, D. Laurent, J.E. Morley, M. Pahor, D. Rooks, R. Roubenoff, S.B. Rutkove, A. Shaheen, S. Vamvakas, J.W. Vrijbloed, B. Vellas Sarcopenia: BIOMARKERS AND IMAGING (International Conference on Sarcopenia Research). Report on the Journal of Nutrition, Health [&] Aging © (Volume 15, Number 10, 2011). PubMed Abstract

Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing, 2010; 39: 412-23. Download pdf

Bauer JM, Kaiser MJ, Sieber CC. Sarcopenia in nursing home residents. J Am. Med. Dir. Assoc., 2008; 9: 545-51. PubMed Abstract

Borst SE. Interventions for sarcopenia and muscle weakness in older people. Age Ageing, 2004; 33: 548-55. Download pdf